Platelet Rich Plasma (PRP) in Arthroscopic Rotator Cuff Repair. A Prospective RCT Study, 2 Years Follow-up

Authors: Pietro Randelli, Paolo Arrigoni, Vincenza Ragone, Paolo Cabitza

References: Presented at ICSES 2010

Hypothesis: Local application of autologous PRP improves tendon healing in patients undergone arthroscopic rotator cuff repair. Study design: Prospective, randomized, controlled, double blind study; Level of evidence, 1. Considering an alpha level of 5%, a power of 80%, 22 patients for group are needed.

Materials and methods: Fifty-three patients who undergone a shoulder arthroscopy for the repair of complete rotator cuff tear, were randomly divided into two groups (block randomization procedure): a treatment group (N=26) who received an intra-operative application of PRP in combination with an autologous thrombin component and a control group (N=27). Patients were evaluated with Validated outcome score. An MRI was performed in all case at more than 1 year post-op. All patients had the same accelerated rehabilitation protocol.

Results: The two groups were omogeneous. Pain score in treatment group was lower than control group at 3, 7, 14 and 30 days after surgery (p<0,05). Strength in External Rotation (dynamometer), SST, UCLA and Constant scores in treatment group were significantly higher than control group at 3 months after surgery (SER: 31,6kg versus 2,11,3kg; SST: 8,92,2 versus 7,12,7; UCLA: 26,93 versus 24,24,9; Constant: 659 vs 57,912; p<0,05). There was no difference between the two groups after 6, 12 and 24 months.The MRI follow-up showed no significant difference in the healing rate. In the subgroup of stage 1 and 2 tears, with less retraction and more prone to the effect of a biological therapy, SER in PRP group were significant higher at 3, 6, 12 and 24 months post-op. (p<0,05).

Conclusions: The results of our study showed autologous PRP reduced pain in the first months post-op and promoted quicker healing. Long-term results of subgroups of stage 1 and 2 tears suggest PRP effectively affected cuff rotator healing.


This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here. satisfies the INTUTE criteria for quality and has been awarded 'editor's choice'.

The material on this website is designed to support, not replace, the relationship that exists between ourselves and our patients. Full Disclaimer